JAMA Associate Editor David L. Simel, MD, MHS, discusses the latest European Society of Intensive Care Medicine (ESICM) Guidelines on Acute Respiratory Distress Syndrome, which were released in June 2023, with Derek C. Angus, MD, MPH, University of Pittsburgh. Related Content: Caring for Patients With Acute Respiratory Distress Syndrome

Derek Angus, Chair of Critical Care Medicine at UPMC, joins the discussion alongside JAMA Editor in Chief Kirsten Bibbins-Domingo. They delve into four pivotal critical care trials recently presented in Melbourne. Topics include the effectiveness of sepsis alert systems that significantly lower hospital mortality, evolving oxygen strategies, and the comparison of high-flow nasal oxygen against non-invasive ventilation. They also explore the impact of biomarker-guided protocols in reducing unnecessary antibiotic use among sepsis patients, emphasizing personalized patient care.