Dr. David Costill, a legend of exercise physiology and human performance, discusses various topics including his career journey, running research, temperature regulation, heart disease and exercise, sports nutrition, caffeine and exercise, and the golden age of exercise physiology. He shares anecdotes about his colleagues, swimming abilities, and his sense of humor. The podcast also touches on topics like the Harvard Fatigue Lab, soleus biopsies, and the importance of rest and tapering in training. Overall, an entertaining and insightful conversation!