David A. Wolk
Neurologist at the Perlman School of Medicine at the University of Pennsylvania. Expert in limbic predominant age-related TDP-43 encephalopathy (LATE).
Best podcasts with David A. Wolk
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Dec 1, 2025 • 1h 21min
180 | Limbic-Predominant Age-Related TDP-43 Encephalopathy (LATE) – A Conversation With Dr. David Wolk
In this enlightening discussion, Dr. David Wolk, a neurology professor and director at the Penn Alzheimer's Disease Research Center, delves into Limbic-Predominant Age-Related TDP-43 Encephalopathy (LATE). He unpacks the role of TDP-43, its ties to ALS and hippocampal sclerosis, and contrasts LATE's clinical profile with Alzheimer's. Wolk highlights crucial diagnostic criteria, advanced neuroimaging markers, and the significance of understanding LATE's prevalence as we age. His insights pave the way for better identification and management of this complex condition.
May 26, 2025 • 21min
Clinical Criteria for LATE
Join Dr. Greg Cooper as he chats with Dr. David A. Wolk, a distinguished neurologist from the University of Pennsylvania, specializing in LATE. They delve into the nuances of limbic predominant age-related TDP-43 encephalopathy, highlighting its critical links to cognitive decline and Alzheimer's disease. The discussion covers the evolving recognition of LATE, challenges in accurate diagnosis, and the importance of advanced biomarkers like FDG PET imaging. Wolk's insights shed light on LATE's distinct clinical features and the urgency for better diagnostic tools.
