Explore the AID-ICU trial investigating the use of Haloperidol for delirium in the ICU, with insights from experts discussing impact, findings, and limitations. Reflect on outcome assessment in clinical trials during a pandemic, patient experiences, and the effectiveness of Haloperidol in treating uncontrollable delirium.

Discussing the evolution of ARDS definitions including the impact of COVID-19. Exploring the use of point-of-care ultrasound in critical care and treating patients based on specific traits. Delving into the long-term impact of ICU interventions on patient outcomes.

Scott Berry and Danny McAuley discuss the results of the statin domain of the REMAP-CAP trial, investigating the effectiveness of simvastatin in treating severe COVID-19. They explore the rationale behind using statins as an intervention, the trial's design and eligibility criteria, and the decision to stop the trial early. The primary outcome and results are presented, highlighting the potential benefits for clinicians. They also discuss response adaptive randomization, the inflammatory phenotype of patients, and the challenges of conducting mechanistic work alongside clinical trials during a pandemic.