Daniel Herman, MD, PhD, from the University of Pennsylvania, dives into the complexities of prenatal screening for open neural tube defects. He discusses the historical implications of race in these screenings, revealing how racial adjustments can lead to misleading false positives, particularly for Black patients. The conversation highlights a significant shift towards race-agnostic approaches, advocating for more equitable prenatal testing methods. Herman emphasizes the necessity for ongoing research to explore new biomarkers that can improve healthcare outcomes for all.