In this discussion, Hussam Tabaja, Supavit "Mac" Chesdachai, and Daniel DeSimone from Mayo Clinic explore the intricate world of vascular graft infections. They emphasize the importance of multidisciplinary teamwork in preventing and managing these infections. The conversation touches on the challenges in diagnosis and preoperative evaluations, illustrated through compelling patient case studies. They also address health disparities and advocate for a collaborative approach to treatment, highlighting the critical role of social determinants in accessing care.