Cullen Buie, a professor of biological engineering at MIT, and Marcelo Gleiser, a professor of physics and astronomy at Dartmouth, explore the often challenging concept of intellectual humility. They discuss why admitting ignorance is crucial in academia and how their religious views promote openness. The conversation highlights the need for collaboration across disciplines to tackle societal issues. Personal anecdotes and literary references underscore how embracing failure can drive both personal growth and innovation.