Dr. Bruno Odisio and Dr. Constantinos Sofocleous discuss the history and advancements in tumor ablation, emphasizing the importance of establishing larger margins for improved outcomes. They also explore the challenges in conducting comprehensive studies due to the presence of multiple ablation technology vendors. The significance of ablation margin confirmation and the use of software for optimal treatment planning is highlighted. The speakers also touch upon the background, design, and industry sponsors of a renowned liver ablation trial, as well as the challenges in assessing ablation confirmation margin.