Claire Harrison

Consultant haematologist at Guy’s and St Thomas’ NHS Foundation Trust with extensive clinical expertise in myeloproliferative neoplasms and clinical trial leadership; contributed clinical interpretation of the INCA33989 data and context on other emerging MPN therapies.

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Jul 14, 2025 • 21min

Targeting mutant CALR in MPNs with antibodies & cellular therapy: the potential for disease modification

This conversation features Claire Harrison, a haematologist with expertise in MPNs, Alex Rampotas, a clinician-researcher focused on CAR-T therapies, Jean-Jacques Kiladjian, a hematologist with a deep understanding of MPN biology, and John Mascarenhas, involved in MPN clinical trials. They explore the potential of targeting mutant CALR in MPNs. Key insights include the promising early results of the INCA33989 trial, the development of CAR-T therapies aimed at mutant CALR, and innovative approaches using organoid models to test immunotherapies effectively.

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