Christos Christou, the international president of Médecins Sans Frontières, shares insights on the ethical dilemmas faced by healthcare workers in conflict zones, emphasizing the vital role of neutrality and international advocacy. Ara Darzi, a surgeon and executive chair of the WISH conference, discusses the urgent need to tackle antimicrobial resistance, spotlighting funding challenges and the importance of diagnostics. Together, they confront the pressing issues of violence against healthcare and the fight against antibiotic resistance while fostering hope for collaborative solutions.