Join Zhongrong Miao, MD, PhD, a medical expert from Beijing Tiantan Hospital, and Christopher C. Muth, MD, JAMA's Deputy Editor, as they dive into the BASIS randomized clinical trial. They discuss the alarming prevalence of intracranial artery stenosis in Asia and its connection to severe patient outcomes. The podcast explores the advantages of balloon angioplasty combined with aggressive medical management, shedding light on its potential to lower long-term stroke and death risks while calling for improved clinician training to mitigate periprocedural complications.