Anastasia “Tash” Theodosiou, a PhD candidate and registrar in infectious diseases, joins Chrissie Jones, an associate professor of pediatric infectious diseases, to tackle the surge in Group A Streptococcus cases in the UK. They delve into differentiating viral from bacterial pharyngitis, effective swabbing practices, and antibiotic treatment strategies. They also address alternative antibiotics, the implications of macrolide resistance, and why clindamycin is crucial in severe cases. Lastly, they explore the global burden of GAS and ongoing efforts for a vaccine.