Dr. Charles Raison and Dr. Rachel Yehuda discuss the potential of psilocybin for treating major depressive disorder. They cover the study design, findings, limitations, side effects, and the importance of blinding in psilocybin research. They also explore the sustained gains in mental health seen after psilocybin treatment. The podcast highlights the unique effects of psilocybin and the need for future research on psychedelic therapies for mental health care.