In this insightful discussion, molecular biologist Stephen Baker, virologist Ian Goodfellow, and infectious disease epidemiologist Caroline Trotter tackle the urgent crisis of antimicrobial resistance (AMR). They explore how the misuse of antimicrobials has accelerated the evolution of resistant pathogens. The guests highlight lessons learned from past pandemics, the complexities of vaccine development, and the critical need for global collaboration to combat future health threats. The conversation also delves into the impact of climate change on infectious disease spread.