Jill Viles, a courageous muscular dystrophy patient, dives into her journey of believing she shares a genetic mutation with Olympic sprinter Priscilla Lopes-Schliep. Joined by journalist David Epstein, they explore the complexities of genetics and athleticism, and Jill's emotional quest for recognition. Meanwhile, Carol Ashton, comedian Tig Notaro’s mother-in-law, shares the joy of her unique joke that only she finds funny, leading to unexpected popularity. Together, these stories highlight the beauty of personal connection and the complexities of humor.