Dr. Karuna Ganesh, a medical oncologist focused on gastrointestinal cancers, and Dr. Caitlin Murphy, an epidemiologist researching young adult cancer outcomes, uncover the alarming rise of cancer in Gen X and Millennials. They explore how prenatal exposures and environmental toxins may play a pivotal role. Discussion also revolves around gut microbiome factors, the exposome concept, and the urgent need for updated screening guidelines. These insights challenge traditional views and aim to reshape cancer prevention strategies for younger generations.