Brian Hie

Brian Hie, a Stanford assistant professor focused on AI in biology, shares groundbreaking insights into how artificial intelligence is transforming biological research. He discusses innovative AI architectures and the surprising capabilities of language models trained on DNA sequences. The conversation explores the role of AI in drug discovery, the evolution of antibodies, and the ethical considerations of employing AI in biotechnology. With an emphasis on interpretability and collaborative efforts, Hie illustrates a promising future where AI unlocks new possibilities in biology.

Brian Hie, a Stanford chemical engineering professor, and Marie Lopez, Head of Genomics AI at InstaDeep, dive into the fascinating world of foundation models. They discuss their applications in analyzing DNA and protein structures, and the challenges of training data biases. Brian highlights the importance of evolutionary priors, while Marie shares insights on using genomic 'grammar' for innovative discoveries. The duo also tackles the limitations and risks of deploying these models in clinical settings, emphasizing the need for validation and transparency.