Hannah Chute, a fourth-year medical student, presents complex clinical cases focusing on diabetic foot infections and endocarditis. Dr. Paloma Reta-Impey, an infectious diseases fellow, discusses the latest guidelines on managing these conditions, emphasizing IV versus oral therapies. Dr. Brad Spellberg, chief medical officer and antibiotic stewardship expert, highlights evidence supporting oral treatments when patients are stable. The conversation delves into patient-centered decision-making, the benefits of oral therapies, and the nuances of managing infections in vulnerable populations.