This engaging discussion features Frank Wilczek, a Nobel-winning physicist, J. Gott, an innovative astrophysicist, Stephen Wolfram, a computer scientist and entrepreneur, philosopher Bas van Fraassen, and astronomer Owen Gingerich. Together, they tackle the profound limits of science in understanding the universe and human existence. Topics include the tension between empirical evidence and spiritual beliefs, the unpredictability of evolution, and the philosophical implications of scientific models versus personal truths. They explore whether real truths exist beyond what science can uncover.