Apkar V. Apkarian, PhD, a trailblazer in neurochemistry at Northwestern University, discusses the fascinating dynamics of pain and the placebo effect. He delves into how pain perception is influenced by brain processes and environmental factors. The conversation highlights the use of meditation in pain management and the remarkable ability of placebos to deliver real relief. Dr. Apkarian also shares ambitious goals to develop new pain relief medications while championing open science, ensuring transformative research is accessible to all.