In this engaging discussion, Anthony O’Hear, Professor of Philosophy at the University of Buckingham, Anthony Grayling from Birkbeck College, and Caroline Warman, Fellow of Jesus College, Oxford, explore the evolution of materialism from ancient Greece to modern science. They tackle its impact on religion and free will, delve into atomism through Epicurus and Lucretius, and dissect the philosophical tensions with Christianity. The conversation highlights materialism's influence on contemporary thought and its relationship with atheism, consciousness, and the foundations of modern science.