Join Roger Rodby, a nephrologist with a wealth of clinical experience, alongside Josh Waitzman, a nephrologist and scientist, Melanie Honig, a clinical contributor, Anna Gaddy, and JC, as they delve deep into metabolic acidosis. They explore the biochemistry of lactate, the Warburg effect in cancer, and treatment controversies surrounding bicarbonate therapy. The panel also navigates risks related to liver dysfunction, toxic ingestions, and the implications of lactate in various clinical scenarios, all while providing fascinating insights into acid-base disorders.