Dr. Anireddy Reddy, a pediatric intensive care attending physician at Children’s Hospital of Philadelphia, dives into the intricacies of oxygen therapy for critically ill children. The discussion highlights a case of a 3-year-old girl with severe respiratory distress, emphasizing careful assessment instead of knee-jerk reactions to low oxygen levels. Dr. Reddy examines a recent clinical trial on conservative versus liberal oxygenation strategies, revealing critical insights about patient outcomes and health disparities in oxygen monitoring.