In this episode, OB Anesthesia fellows Dr. Dave Berman and Dr. Anh Nguyen discuss medications for neuraxial anesthesia, including local anesthetics, opioids, and adjuncts such as clonidine and epinephrine. They delve into topics like the basic science of local anesthetics, the use of fentanyl in neuraxial anesthesia, and the controversy surrounding the use of sodium bicarbonate. They also explore the benefits and drawbacks of clonidine as an adjuvant, and touch on experimental medication practices involving magnesium, ketamine, and neostigmine. Exciting insights for those interested in anesthesia!