Messoud Ashina, Director of the Human Migraine Research Unit in Copenhagen, and Andrea Cipriani, Professor of Psychiatry at the University of Oxford, dive into the complexities of treating migraine. They discuss licensed drug interventions for acute migraine management, highlighting challenges in current treatments and the need for patient input. They tackle the efficacy of both traditional and new medications, emphasizing the importance of tailoring treatments to individual needs, and the critical role of neurologists in improving patient outcomes.