Dr. Amy Mathers, a microbiology expert and IDSA guidance author, joins Dr. Julie Ann Justo, a clinical pharmacist specializing in infectious diseases, for an insightful discussion. They explore the challenges of treating Stenotrophomonas maltophilia, a tricky pathogen known for its resistance. The conversation delves into effective combination therapies and the significance of updated treatment guidelines. They also examine pharmacokinetics, particularly the efficacy of tetracyclines and fluoroquinolones, while emphasizing the importance of tailored approaches for vulnerable patient populations.