Ammar Al-Chalabi and Merit Cudkowicz, leading experts in ALS research, delve into the complexities of amyotrophic lateral sclerosis. They discuss how ALS impacts the body and brain, highlighting genetic predispositions and emerging environmental risks. The duo explores breakthroughs in gene therapy that may reverse the disease's effects, alongside the role of lifestyle and multidisciplinary care in patient management. They also reflect on the Ice Bucket Challenge's transformative impact on ALS awareness and funding.