Dr. Amit Chopra discusses the intricate relationship between insomnia and major depressive disorder, highlighting its impact on treatment outcomes and neurobiology. Topics include antidepressants' effects on REM sleep, changes in insomnia definition, and addressing insomnia to prevent depression relapse.

Dr. Amit Chopra, a psychiatrist and sleep specialist at Massachusetts General Hospital and Harvard Medical School, delves into innovative pharmacological treatments for insomnia related to major depression. He discusses the intriguing benefits of dual orexin receptor antagonists and melatonin agonists, as well as the effectiveness of low-dose doxepin. Additionally, Chopra explains the pitfalls of traditional therapies and emphasizes integrating cognitive behavioral therapy for optimal patient outcomes.