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Akshay Sharma
MBBS, MSc, St. Jude Children’s Research Hospital, Memphis, TN. Provides insights into gene therapy for sickle cell disease (SCD), including patient selection, complications, and the risk of leukemia after lentiviral gene therapy.
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May 23, 2025
• 21min
Gene therapy in sickle cell disease: patient selection, potential complications, & more
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In this insightful discussion, Dr. Akshay Sharma, a hematologist at St. Jude Children’s Research Hospital, explores the cutting-edge field of gene therapy for sickle cell disease. He details key considerations for selecting patients, emphasizing organ function and pre-existing health conditions. The conversation highlights the complex benefits and challenges of gene therapy, including the risk of leukemia linked to lentiviral treatments. Additionally, Dr. Sharma addresses the evolving role of palliative care in enhancing patient comfort during such innovative therapies.
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