In the U.S., Black women are 3 times more likely to experience infant mortality and previously healthy Black children are 3.4 times more likely to die within 30 days after a surgery. What do these statistics – and many others around healthcare, housing and other topics – have to do with vaccine hesitancy? Everything. Latasha Easter, MD, a pediatric resident at Children’s Hospital of Philadelphia, provides an overview of: disparities in immunization rates; the historical context for distrust of the medical establishment and government among Black patients, and the importance of acknowledging it; the CASE Approach, a framework for conversations with hesitant families; sample conversations and responses; an HPV vaccination success story; social media as an information source; and more. This podcast is for general informational and educational purposes only and is not to be considered as medical advice for any particular patient. Clinicians must rely on their own informed clinical judgment in making recommendations to their patients. ©2022 by Children's Hospital of Philadelphia, all rights reserved.