ICU Primary PrepCast Epi 96 - ICU Primary Snippet 39 - Lactate
Apr 7, 2025
Explore the fascinating world of lactate, from its formation during anaerobic conditions to its critical role in metabolism. Learn how lactate is involved in pathways like gluconeogenesis and the Cori cycle, providing essential energy in critical care settings. Discover how lactate isn't just a byproduct but a key player in athletic performance, fueling endurance athletes through intense training. This insightful discussion connects biochemistry with real-world health and performance, making lactate a star in metabolic processes.
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Lactate Production
- Lactate production occurs in various body parts, with skin and muscles being major contributors.
- Production increases during exercise, and the placenta becomes a significant source during pregnancy.
Factors Influencing Lactate Levels
- Increased lactate levels can stem from higher pyruvate production, decreased utilization, or reduced clearance.
- Several factors can influence these processes, such as hypoxia, enzyme deficiencies, and organ dysfunction.
Lactate Metabolism
- Lactate metabolism primarily happens through gluconeogenesis in the liver and kidneys, and oxidation in various organs.
- The Cori cycle plays a crucial role by transporting lactate from muscles to the liver for conversion back to glucose.