This Week in Virology TWiV 1276: Clinical update with Dr. Daniel Griffin
16 snips
Dec 6, 2025 
Dr. Daniel Griffin, an infectious disease clinician and weekly commentator, discusses intriguing findings, including how the shingles vaccine may lower dementia rates. He critiques FDA claims linking COVID vaccines to children's deaths, updates on the measles epidemic, and shares insights on rising respiratory viruses like RSV and H3 influenza. Griffin also highlights the benefits of one-dose HPV vaccination and addresses long COVID symptoms, including neurodegenerative changes and effective treatments like celiac plexus blocks.
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Shingles Vaccine Linked To Fewer Dementia Outcomes
- Shingles vaccination is associated with reduced new mild cognitive impairment and fewer deaths due to dementia over nine years in a Welsh cohort.
- The protective effect is strongest among those who actually received the vaccine, not just those eligible.
Leaked Memo Uses VAERS Without Evidence
- A leaked FDA memo claim linking 10 child deaths to COVID vaccines used VAERS mining and provided no verified evidence.
- Daniel Griffin and Vincent Racaniello criticized the letter as scientifically weak, accusatory, and potentially politically motivated.
One HPV Dose May Be Enough
- Consider single-dose HPV vaccination as it was noninferior to two doses for preventing persistent HPV-16/18 infection in a NEJM randomized trial.
- Expanding single-dose schedules could improve uptake and reduce HPV-related cancers if adopted in guidelines.
