Diabetes Core Update

Diabetes Core Update – February 2024

Jan 24, 2024

This podcast discusses various topics related to diabetes, including the treatment and monitoring of obesity, the detection of cardiovascular disease in patients with COPD and type 2 diabetes, the importance of EKG and BNP testing in diagnosing cardiovascular risk, the use of low-dose anti-thymocyte globulin in treating type 1 diabetes, and the connection between 'burned out diabetes', anemia, and hypoglycemia in dialysis patients.

33:29

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Quick takeaways

Continued treatment with terzepitide, a GLP1GIP agonist, resulted in superior weight reduction in adults with obesity compared to placebo.

Adding a GLP1 to patients already on metformin did not increase gastrointestinal side effects and may even decrease adverse events.

Deep dives

Trial shows continued treatment with terzepitide for weight reduction in adults with obesity

In a randomized clinical trial, it was demonstrated that continued treatment with terzepitide, a GLP1GIP agonist, resulted in superior weight reduction compared to placebo over the course of 88 weeks. Participants who stayed on the maximum tolerated dose of terzepitide achieved approximately 26-27% total body weight loss, while those on placebo regained the majority of their weight. The trial highlighted the importance of staying on medication to maintain weight reduction in adults with obesity.

Introduction

2min

Trial Results on Terzepitide for Obesity Treatment

10min

Opportunity to Join ADA and Proactive Diagnostic Strategy for Cardiovascular Disease Detection in Patients with COPD and Type 2 Diabetes

4min

Importance of EKG and BNP Testing in Diagnosing Cardiovascular Risk in Patients with Diabetes

3min

Low-Dose Anti-Thimocyte Globulin for Type One Diabetes

11min

Associations between 'burned out diabetes', anemia, and hypoglycemia in dialysis patients

3min

Diabetes Core Update is a monthly podcast that presents and discusses the latest clinically relevant articles from the American Diabetes Association’s four science and medical journals – Diabetes, Diabetes Care, Clinical Diabetes, and Diabetes Spectrum. Each episode is approximately 25 minutes long and presents 5-6 recently published articles from ADA journals.

Intended for practicing physicians and health care professionals, Diabetes Core Update discusses how the latest research and information published in journals of the American Diabetes Association are relevant to clinical practice and can be applied in a treatment setting.

Welcome to diabetes core update where every month we go over the most important articles to come out in the field of diabetes. Articles that are important for practicing clinicians to understand to stay up with the rapid changes in the field.

This issue will review:

1. Continued Treatment With Tirzepatide for Maintenance of Weight Reduction in Adults With Obesity: The SURMOUNT-4 Randomized Clinical Trial

2. Occurrence of Gastrointestinal Adverse Events Upon GLP-1 Receptor Agonist Initiation With Concomitant Metformin Use

3. Diagnostic yield of a proactive strategy for early detection of cardiovascular disease vs usual care in adults with type 2 diabetes or chronic obstructive pulmonary

4. Low-Dose Anti-thymocyte Globulin: Treating Stage 2 Type 1 Diabetes

5. Assessment of Glycemic Control by CGM, Hemoglobin A1c, Fructosamine and Glycated Albumin in Patients with End-Stage Kidney Disease and Burnt-Out Diabetes

For more information about each of ADA’s science and medical journals, please visit www.diabetesjournals.org.

Hosts:

Neil Skolnik, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health

John J. Russell, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Director, Family Medicine Residency Program, Chair-Department of Family Medicine, Abington Jefferson Health

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