Depressed and Always Tired? How Genetic Testing May Unlock New Answers

Are you living with depression and extreme fatigue that never seems to improve?

In this powerful episode, Scott, a husband and father, shares his journey of living with depression and exhaustion—and how a simple genetic test revealed an MTHFR gene mutation that changed his treatment path.

After the devastating loss of his grandmother and a flare of depression and suicidal thoughts, Scott sought help from a therapist who suggested genetic testing. What he discovered explained his low energy, depression, and anxiety—and with a simple prescribed supplement, he experienced a life-changing difference in just weeks.

This episode explores how genetic testing for depression and fatigue can open new treatment options, why so many people carry the MTHFR mutation without knowing it, and how lifestyle and diet changes can also help.

If you’ve ever wondered why you’re always tired and depressed despite treatment, Scott’s story may offer new hope.

Link to research article: https://ghr.nlm.nih.gov/gene/MTHFR#

Link to more of an informal explanation: https://www.psychologytoday.com/us/blog/the-integrationist/201409/genetic-mutation-can-affect-mental-physical-health

Primary Topics Covered:

• Scott’s lived experience with depression, anxiety, and exhaustion
• The loss that triggered a severe depressive episode
• Why suicidal thoughts often accompany major depressive relapses
• How his therapist suggested genetic testing for depression treatment
• What the MTHFR gene mutation is and how it affects energy and mood
• The affordable test that revealed Scott’s mutation
• How supplements and lifestyle changes can improve depression symptoms
• The importance of sharing discoveries to help others with depression

Timestamps:

00:00 – Introduction to today’s episode
 01:33 – Scott’s journey: from listener to guest
 02:21 – What sparked his curiosity about genetic testing
 03:34 – Life crisis: loss of his grandmother and relapse into depression
 04:05 – The return of suicidal thoughts
 04:29 – His wife activates family support and encourages therapy
 04:50 – Intake session: describing exhaustion as his main symptom
 05:34 – The therapist suspects an MTHFR gene mutation
 06:10 – A blood test confirms the genetic mutation
 06:51 – Learning he cannot process B vitamins effectively
 07:05 – Prescription supplement brings dramatic changes
 08:21 – Scott describes newfound energy and relief from fatigue
 09:08 – Why he wanted to share his discovery with others
 09:23 – The power of community in mental health recovery
 10:12 – Broader discussion: 30–45% of people may carry this mutation
 11:45 – Lifestyle, diet, and stress-reduction strategies that help
 13:08 – Co-hosts reflect on testing and their own fatigue
 14:26 – Closing thoughts and resources

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