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Healio Rheuminations

all CAPS: A Story of Ice and Fire - Part 2

Nov 27, 2019
28:37

Things get a little nerdy in this episode, which focuses on the basic science of what makes the inflammasome tick in CAPS, as well as data on the use of interleukin 1 inhibition. Hint: Listen to “The Inflammasome for Dunces” episode first, and this one will make more sense.

  • Intro :20
  • Recap of Part 1 :33
  • Overview of this episode 1:56
  • Familial cold autoinflammatory syndrome 3:04
  • Muckle-Wells syndrome 6:34
  • The two checkpoint problem 8:36
  • What do we know about the inhibition of the inflammasome? 11:13
  • Back to the trebuchet analogy 11:48

Brought to you by GSK. Considering a treatment change for patients with active SLE? Learn about a treatment option for your patients at treatfortodayandtomorrow.com

  • A paper on CARD8 in the setting of CAPS 13:50
  • Let’s talk about prostaglandins 15:27
  • There are over 100 mutations in CAPS 18:15
  • Let’s talk about treatment 18:42
  • One caveat 25:41
  • That’s CAPS 26:45
  • Reach out to me via email and on Twitter 27:03
  • Episode recap 27:41

We’d love to hear from you! Send your comments/questions to rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum

Brought to you by GSK. Consider the long-term impact of disease activity, flares and corticosteroid use on patients with active SLE. Learn more now at treatfortodayandtomorrow.com.

Disclosure: Brown reports no relevant financial disclosures.

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Marsaud C, et al. J Rheumatol. 2014;41:1721-1722.

Hawkins PN, et al. NEJM. 2003;348:2583-2584.

Hoffman HM, et al. Lancet. 2004;364:1779-1785.

Hoffman HM, et al. Clin Ther. 2012;34:2091-2103.

Ito S, et al. Arthritis Res Ther. 2014;16:doi:10.1186/ar4483.

Kuemmerle-Deschner JB, et al. Ann Rheum Dis. 2011;70:2095-2102.

Lachmann HJ, et al. NEJM. 2009;360:2416-2425.

Mamoudjy N, et al. Orphanet J Rare Dis. 2017;12:doi:10.1186/s13023-017-0589-1.

Rosengren S, et al. J Allergy Clin Immunol. 2007;119:991-996.

Ross JB, et al. J Cutan Med Surg. 2008;12:8-16.

Tassi S, et al. Proc Natl Acad Sci USA. 2010;107:9789-9794.

Thornton BD, et al. Am J Kidney Dis. 2007;49:477-481.

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