E250 - Sexual Dysfunction: The Least Talked about Side Effect with Anita Clayton, MD

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Mar 12, 2025

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INSIGHT

Understanding Sexual Dysfunction

Sexual dysfunction includes hypoactive desire, arousal issues, and orgasmic problems which can be caused by medications or occur spontaneously.
Depression often coexists with sexual dysfunction and complicates diagnosis and treatment.

INSIGHT

Medication Classes & Sexual Dysfunction

SSRIs cause sexual dysfunction in 70-80% of patients, while SNRIs and atypicals have lower rates based on their mechanisms.
Medication choice affects sexual side effects due to neurotransmitter impacts like serotonin and norepinephrine balance.

ADVICE

Normalize Sexual Side Effect Discussion

Clinicians should not be shy; normalize sexual health discussions by asking patients about sexual function and preferences.
Using tools like the Changes in Sexual Functioning Questionnaire helps open dialogue and track issues proactively.

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Join Dr. Andy Cutler as he speaks with Dr. Anita Clayton about one of the most common yet least discussed side effects of psychotropic medications—sexual dysfunction. They explore the different aspects of sexual dysfunction that may arise as a side effect, how to distinguish these from symptoms of psychiatric or medical disorders, and how to collaborate with patients to effectively address this challenging issue.

Anita H. Clayton, MD, Wilford W. Spradlin Professor and Chair of Psychiatry & Neurobehavioral Sciences, and Professor of Clinical Obstetrics & Gynecology at the University of Virginia School of Medicine, has focused her research on major depressive disorder, mood disorders associated with reproductive-life events in women (reproductive psychiatry), sexual dysfunction related to illness and medications, and the assessment and treatment of primary sexual disorders.

Andrew J. Cutler, MD is a distinguished psychiatrist and researcher with extensive experience in clinical trials and psychopharmacology. He currently serves as the Chief Medical Officer of Neuroscience Education Institute and holds the position of Clinical Associate Professor of Psychiatry at SUNY Upstate Medical University in Syracuse, New York.

Resources

Changes in Sexual Functioning Questionnaire short- form (CSFQ-14)

Validation study for CSFQ-14

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