Mark Cuban’s disruption formula: from streaming and healthcare to AI’s next wave

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Aug 27, 2025

Mark Cuban, a business icon and owner of the Dallas Mavericks, shares his insights on identifying disruptive opportunities across various industries. He emphasizes the importance of spotting patterns for billion-dollar innovations, suggesting that the current AI gold rush is missing the point. He argues that real success lies in helping small businesses integrate AI effectively. Cuban also discusses healthcare pricing transparency through Cost Plus Drugs, advocating for fairer access, and warns about the upcoming regulatory battles in the AI landscape.

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ANECDOTE

Early Bets On Emerging Tech

Mark Cuban described founding early companies like MicroSolutions, AudioNet and HDNet that pioneered LANs, streaming and HD TV.
He greenlit the documentary Enron quickly and said the film's Oscar nomination made him believe the movie business was easy.

INSIGHT

Remix As A Disruption Framework

Cuban cites Steve Jobs' 'everything's a remix' and looks for ways to recombine tech into novel businesses.
He says spotting patterns and turning them into new applications is the core of disruption.

ADVICE

Three Questions To Evaluate Founders

Ask founders if they are technical, can sell, and have gone to customers before investing.
Focus on product-market fit first, then scale once founders demonstrate traction.

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Steve Jobs once said, “Everything’s a remix.” And that’s a philosophy that Mark Cuban has taken to heart, building an entire entrepreneurial and investment career on that simple belief. The real opportunity, Cuban says, lies in spotting patterns others miss and turning them into billion-dollar disruptions.

On today's episode of Equity, Cuban joined Rebecca Bellan to discuss his decades-long strategy of betting on technologies before they go mainstream, from his early investments in local area networks and streaming services to his current healthcare and AI ventures. But Cuban's real insight isn't just about picking winners. It's about understanding why most people building in AI today are missing the point entirely.

Cuban delivered a stark warning about the current AI gold rush: while everyone's using ChatGPT, almost no one (including Fortune 500 CEOs) knows how to integrate AI into their actual businesses. His take? Forget the hype. The real money is in helping small- and medium-sized businesses figure out how to use the AI tools that already exist.

Listen to the full episode to hear:

How Cuban identified disruptive opportunities in LANs, streaming, and HD television before they became obvious.
Why he thinks current AI "isn't smart," and why that limitation could be its strength as a business tool.
The upcoming regulatory battles that will determine AI's future around IP protection, training data access, and the U.S.-China competition.
Inside Cuban's latest venture, Cost Plus Drugs, expanding from transparent pricing to manufacturing.
Cuban's prediction that AI-savvy graduates will become the most in-demand employees across every industry.

As always, Equity will be back Friday. Don’t miss it!

Equity is TechCrunch’s flagship podcast, produced by Theresa Loconsolo, and posts every Wednesday and Friday.

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