Over 40 Fitness Hacks 463: Leslie Kenny - Spermadine Supplement Shows Links To Autophagy, Mitophagy, and Lipophagy
Spermadine Supplement Shows Links To Autophagy, Mitophagy, and Lipophagy
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Leslie Kenny - Oxford Healthspan
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In this podcast episode of Over 40 Fitness Hacks, host Brad Williams interviews Leslie Kenny from Oxflord Healthspan about the benefits of spermidine, a compound with potential anti-aging properties. Brad introduces himself as a personal trainer with over 14 years of experience and expresses his focus on helping the over 40 crowd maintain fitness while enjoying their social lives.
Leslie discusses how spermidine aids in the conversion of white adipose tissue to brown adipose tissue, which boosts metabolism and aids in weight loss. Additionally, spermidine shows promise in reversing damage caused by overindulgence in carbs and sugar, such as nonalcoholic fatty liver disease.
The conversation delves into spermidine's potential benefits for liver health, including its ability to reverse damage caused by excessive alcohol consumption. Leslie highlights the findings from animal studies and emphasizes spermidine's safety as a food-derived compound.
They further explore spermidine's role in various metabolic processes, including autophagy, mitophagy, and lipophagy, which contribute to energy production and lipid metabolism. Leslie compares spermidine's effects to other supplements and discusses its accessibility through diet and supplementation.
Leslie explains how spermidine aligns with the hallmarks of aging and its potential to inhibit nine out of twelve aging pathways. She emphasizes the importance of autophagy in cellular repair and highlights Japan's initiatives to promote research on autophagy and aging.
Brad reflects on the evolving landscape of health and wellness, noting the importance of staying informed and balancing aesthetic goals with internal health. Leslie discusses spermidine's benefits for external appearance, citing improvements in hair, skin, and nails.
Overall, the podcast provides insights into spermidine's potential as an anti-aging compound and its broader implications for health and wellness, particularly for individuals over 40 seeking to optimize their fitness and longevity.
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