4 Keys to Allo in 2024 with Poseida Therapeutics' Kristin Yarema, Ph.D.
Jan 4, 2024
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Poseida Therapeutics' CEO Kristin Yarema discusses the challenges of developing off-the-shelf therapies in CGT sector. She highlights the potential progress in allogeneic therapies by 2024. Topics include nanoparticle delivery, allogeneic T cell therapies, strategic investments, manufacturing scale up, and personal plans for 2024.
Poseida Therapeutics is aiming to make significant progress in allogeneic therapies by 2024.
Allogeneic T-cell therapies can meet the demand for more patients, are cost-effective, and offer volume and flexibility for patient access.
Deep dives
Poseida's Focus in Cell Therapy: Fully Allogeneic Approach
Poseida Therapeutics is focusing on a fully allogeneic approach in cell therapy. They initially worked on autologous CAR-T cell therapies but quickly shifted towards allogeneic approach. They now have three clinical stage programs, two in hematological malignancies and one in solid tumors. Their goal in 2024 is to execute and advance their pipeline in clinical development, while maintaining their unique culture at Poseida. They also emphasize the importance of their manufacturing capabilities, as they have their own clinical manufacturing facility to support all their programs.
Benefits of Allogeneic T-Cell Therapies
Poseida believes that allogeneic T-cell therapies can be as effective, if not better, than autologous T-cell therapies. They argue that allogeneic therapies can meet the demand for larger numbers of patients and can be easily distributed to multiple centers, easily used, and available on demand. They also emphasize the cost-effectiveness of allogeneic therapies, as they believe they can produce their therapies at $10,000 per dose or less. By focusing on the T stem cell memory cell, Poseida aims to develop a product that is different from current therapies and offers the volume and flexibility needed for patient access.
Poseida's Pipeline and Focus on Scalable Allogeneic Approaches
Poseida's unique approach focuses on the T stem cell memory cell, which has been shown to correlate well with clinical responses. They utilize non-viral transposon and gene editing technologies to insert genes into these cells, preserving their stem cell memory phenotype. Poseida has three clinical stage programs: PBCMA-ALO-1 for BCMA-directed CAR-T in hematological malignancies, PCD-19CD-20ALO-1 for dual ALO CAR-T in B-cell malignancies, and a program against MUC-1C in solid tumors. These programs are in Phase 1 and are expected to report data in 2024. Poseida's focus on scalability extends to their manufacturing process, ensuring that their therapies can be produced at scale to meet patient needs.
Kristin Yarema, Ph.D., CEO, Poseida Therapeutics sits down with Cell & Gene: The Podcast Host Erin Harris to discuss four of the biggest challenges the CGT sector faces when it comes to the development of off-the-shelf therapies. Kristin shares how 2024 might see some real progress in allogeneic therapies.