The use of COA in patient-centered drug development: part 2
Apr 10, 2024
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Health technology assessment expert Paul Miller and patient-reported outcomes specialist Olivier Wong delve into the integration of patient perspectives in decision-making processes, the significance of high-quality patient experience data, the challenges of aligning methodologies for joint clinical assessments, and the evolution of patient-reported outcomes in health technology assessment.
Scientific rigor in capturing patient experience data is crucial in incorporating PROs effectively into the HTA process.
Harmonization across different health systems is a challenge for standardized incorporation of PROs in decision-making processes.
Deep dives
Usage of Patient Reported Outcomes (PROs) in Health Technology Agencies (HTAs)
Patient Reported Outcomes (PROs) have gained importance in health technology agency decision-making processes. Documentation, like the Nice Health Technology Evaluations Manual, includes guidelines for capturing patient and caregiver experiences. However, while there is recognition of the importance of patient experiences, challenges remain in scientific methodologies for incorporating PRO data effectively into the HTA process. There is a push towards increasing scientific rigor in capturing patient experience data and addressing the methodological considerations.
Updates in PRO Guidance
Guidance on PROs in health technology assessments have been regularly updated, with recent official publications as of 2022. The emphasis on high-quality data in PRO assessments has led to the requirement of robust scientific standards in the use of alternative PROs beyond the standard EQ5D measure. The shift towards incorporating patient perspectives scientifically aligns the efficacy outcome measures from patient data more closely with traditional clinical efficacy measures.
Harmonization Challenges in PRO Usage
While there is a global trend towards considering PROs in HTAs, challenges in harmonization persist across different health systems. Variations exist in the types of patient experience data required by different agencies, leading to difficulties in meeting diverse stakeholder needs. The lack of joint guidance and differing expectations across HTAs pose hurdles for standardized incorporation of PROs in decision-making processes.
Future Prospects for PROs in HTA Decision Making
The future outlook for Patient Reported Outcomes (PROs) in HTA assessments suggests an increasing emphasis on their use and utility. With the European framework mandating the consideration of PROs, there is a growing need for high-quality data and methodology adherence in PRO assessments. The potential for harmonization across HTAs in evaluating PROs may offer a more standardized approach towards incorporating patient-centered data in decision-making.
This week, we're putting the PRO in PROgress by discussing Patient Reported Outcomes with guests Paul Miller and Olivier Wong. In particular, how they're shaping the world of health technology assessment.
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