JAMA Network JAMA Otolaryngology–Head & Neck Surgery : Stellate Ganglion Block for the Treatment of COVID-19−Induced Parosmia
Aug 14, 2025
Nyssa Fox Farrell, an otolaryngologist specializing in COVID-related olfactory dysfunction, joins pain management specialist Lara W. Crock to discuss their research on using stellate ganglion blocks for treating COVID-19 induced parosmia. They share compelling patient stories and explore the innovative application of this technique for olfactory dysfunction. The conversation delves into the historical context of stellate ganglion blocks, challenges in study methodologies, and the importance of ethical practices in developing effective treatments.
AI Snips
Chapters
Transcript
Episode notes
Social Media Sparked Clinical Inquiry
- Nyssa Farrell describes learning about SGB from social media reports of dramatic smell recovery after long-term loss.
- She partnered with Laura Crock, an SGB expert, to investigate the phenomenon clinically.
Established Technique With New Application
- Lara Crock explains SGB is a century-old technique used mainly for complex regional pain syndrome and PTSD.
- Prior observational data from Korea suggested SGB might help post-viral olfactory dysfunction, supporting further study.
Pilot Trial Showed a Signal
- Farrell recounts a prior 20-patient pilot where about half had subjective smell improvement after SGB.
- The pilot showed a signal but not definitive results, prompting a larger randomized trial.