The Curious Clinicians 111 - Null Neutrophils
Jul 2, 2025
Curious about the connection between Duffy Null status and neutrophil counts? The discussion dives into the historical context of the Duffy antigen and its vital role in red blood cells. Learn how Duffy null status impacts immune responses and why accurate terminology is crucial in healthcare. The podcast even touches on the antigen's evolutionary significance in malaria resistance and its implications for oncology. It's a fascinating blend of physiology and clinical insights that challenges conventional perspectives!
AI Snips
Chapters
Transcript
Episode notes
Dr. Lauren Murs' Impact
- Dr. Lauren Murs' research at Brigham and Women's Hospital led to renaming benign ethnic neutropenia to Duffy Null Associated Neutrophil Count.
- The change emphasizes genetic basis and avoids race-based medical terminology, highlighting evolving understanding.
Duffy Antigen Function
- The Duffy antigen, named after a patient, is a glycoprotein on red blood cells and endothelial cells.
- It acts as a receptor for chemokines, linking red blood cell surface proteins to immune system modulation.
Neutrophil Count Differences
- Median neutrophil counts are significantly lower in Duffy null individuals, around 2,800 to 3,300 compared to 4,800 in others.
- This difference is clinically significant but does not necessarily indicate pathology.