Practical Neurology Podcast Posterior cortical atrophy, mascara staining, and careers in stroke - Editors' Highlights February 2025
Jan 22, 2025
Delve into the complexities of Stiff Person Syndrome and emerging treatments for multiple sclerosis. Discover innovative rehabilitation strategies for posterior cortical atrophy, a lesser-known variant of Alzheimer's. Explore the evolving landscape of neurology, including new guidelines for MS and insights into stroke as a career option for neurologists. Plus, learn about effective management techniques for cryptococcal meningitis and a surprising substitute for traditional diagnostic methods.
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Diagnosing Stiff Person Syndrome
- Consider stiff person syndrome if a patient presents with stiffness and spasms, especially with a bizarre gait.
- Test for anti-GAD antibodies early, particularly in CSF, as it's a powerful diagnostic tool.
Psychiatric Component of Stiff Person Syndrome
- Stiff person syndrome often involves a psychiatric component, more so than other stiffness-causing conditions like MS.
- Be mindful of patients' potential requests for benzodiazepines or morphine, which can exacerbate the problem.
ABN Guidelines for MS Treatment
- ABN guidelines on disease-modifying treatments for MS offer a clinician's perspective, prioritizing patient benefit over cost-effectiveness.
- While NICE guidelines consider cost, ABN guidelines focus on what's best for patients, informed by clinical experience.