#163 - When Do Ketone Esters Work Best? Making Sense of Conflicting Data on Exogenous Ketones · Research Roundup

"Exogenous ketosis impacts neither performance nor muscle glycogen breakdown in prolonged endurance exercise".

This is the title of a recent study on exogenous ketones impact on performance, and published by Professor Peter Hespel in The Journal of Applied Physiology.

However, previous seminal research, including a study from Prof. Hespel and published in the same journal, found results that were strikingly different.

"Ketone ester supplementation blunts overreaching symptoms during endurance training overload".

One of the key findings of that study was that ketone ester intake following exercise markedly blunts the development of physiological symptoms indicating overreaching, and at the same time significantly enhances endurance exercise performance.

A finding from this new study comes to the conclusion that ketone ester consumption during a simulated cycling race does not cause glycogen sparing, nor does it affect all-out performance.

How does one make sense of conflicting (or even neutral) data?

Geoffrey Woo and Dr. Latt Mansor (Research Lead at HVMN), are here in an episode of Research Roundup to break all this science down and provide clarity on when exogenous ketones work best, and where further research is needed (which seems to almost always be the case, right everyone? 😉).

 

References:

https://journals.physiology.org/doi/full/10.1152/japplphysiol.00092.2020#B33

https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP277831

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556006/

H.V.M.N. Ketone: https://go.hvmn.com/ketone-pod

 

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