Better Brain Fitness (a Brainjo Production) #72: Hormone Replacement Therapy: A Secret Weapon Against Dementia?
Apr 15, 2025
Discover the intriguing relationship between hormone replacement therapy (HRT) and dementia risk in women. The hosts dive into the historical evolution of HRT, highlighting its changing perceptions and impacts on women's health. They discuss critical factors like timing and dosage that influence cognitive outcomes. Personalized approaches in hormone management are emphasized, urging tailored discussions with healthcare providers. Tune in for insights that could reshape how we think about HRT and brain health.
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History of Early HRT
- Early hormone replacement therapy used conjugated equine estrogen from pregnant mare urine, marketed as a fountain of youth.
- Adding progesterone became necessary to prevent increased uterine cancer risk from unopposed estrogen.
Women’s Health Initiative Lessons
- The 2002 Women's Health Initiative study showed increased risks with HRT but had critical limitations like late intervention and synthetic hormones.
- Later analyses found benefits when HRT started closer to menopause, highlighting context importance.
Hormones’ Brain Benefits Uncertain
- Estrogen and progesterone support brain health through multiple mechanisms like reducing inflammation and enhancing plasticity.
- Clinical trial results on HRT's effects on cognition and dementia risk are mixed and context-dependent.
