Latent Space: The AI Engineer Podcast Priscilla Chan and Mark Zuckerberg: Frontier AI + Virtual Biology To Solve All Diseases
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Nov 6, 2025 
Priscilla Chan, a physician and co-founder of the Chan Zuckerberg Initiative, and Mark Zuckerberg, an engineer and philanthropist, dive into the transformative world of AI and biology. They discuss building advanced microscopes to improve data collection and creating virtual cell models that could revolutionize disease treatment. The conversation highlights the synergistic potential of AI-driven insights in advancing precision medicine and developing a virtual immune system, accelerating the timeline to cure all diseases.
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Tools Drive Scientific Breakthroughs
- Building new scientific tools often precedes major breakthroughs because better observation enables new discoveries.
- Biohub focuses on operating labs and building instruments rather than only funding external grants to accelerate tool development.
Seating Sparks Cross-Discipline Work
- Mark describes how simply seating biologists and engineers together produced hybrid researchers and faster progress.
- The Biohub model deliberately colocates teams across institutions to create that interdisciplinary mix.
Hierarchical Modeling From Proteins To Systems
- Build models hierarchically from proteins up to cells and then tissues so each level supports the next.
- Understanding proteins enables better cellular models, which then enable system-level simulations like a virtual immune system.