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Blood Cancer Talks
Episode 36. ASH 2023 Lymphoma Recap with Dr. Toby Eyre
Dec 20, 2023
Dr. Toby Eyre, a consultant haematologist at the University of Oxford in the UK, joins the hosts to review the hottest updates in lymphoma from the ASH 2023 meeting. They discuss topics like the promising results of a novel triplet treatment for mantle cell lymphoma and the challenges of conducting trials in high-risk groups. They also explore the question of stopping therapy without consolidation, the use of a BCL2 inhibitor in lymphoma treatment, and the comparison of different treatments for CLL and Hodgkin lymphoma.
50:59
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Quick takeaways
- The BOVen trial demonstrated promising results for TP53-mutated mantle cell lymphoma, with a high complete response rate and improved progression-free survival.
- The SYMPATICO trial suggests a potential new standard of care for relapsed and refractory mantle cell lymphoma using Ibrutinib plus phonetic lacs with the addition of rituximab.
Deep dives
The Bovin trial shows promising results for TP53-mutated mantle cell lymphoma
The Bovin trial focused on TP53-mutated mantle cell lymphoma, a high-risk subgroup with poor outcomes. The trial combined Zana-brute plus phonetic lacs and a bit of twos map. The results showed a high complete response rate and undetectable minimal residual disease rates. Two-year progression-free survival was over 70%, representing a significant advancement in treatment options for this high-risk patient population.
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