This Week in Cardiology Oct 10 2025 This Week in Cardiology
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Oct 10, 2025 Discover the latest on GLP-1 agonists for heart failure with reduced ejection fraction, including safety signals and prior trials. Delve into the challenges of left atrial posterior wall isolation with pulse field ablation. Learn about innovative strategies for reducing peri-device leaks in Watchman implants and new insights on atrial fibrillation post-cardiac surgery, highlighting its prevalence and duration. Finally, explore whether intracardiac echo could replace transesophageal echo in AF ablation procedures.
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Prophylactic Pacing Debate And Listener Corrections
- John Mandrola recounts listener feedback about prophylactic pacing after TAVI and his initial critique.
- He acknowledges errors and thanks listeners who corrected his interpretation about pacing percentages and paroxysmal AV block.
GLP‑1s May Harm Patients With HFrEF
- Observational data suggest GLP-1 agonists raise heart rate and may increase arrhythmias in HFrEF patients.
- Existing randomized trials show no benefit and possible harm, so GLP-1s may not be helpful in HFrEF.
PFA Posterior Wall Lesions May Lack Durability
- Pulse field ablation (PFA) makes posterior wall isolation easy but lesion durability is uncertain.
- Epicardial mapping after PFA showed persistent voltage, questioning transmurality and long-term efficacy.