Bloomberg Businessweek The Fight Against Alzheimer’s Disease
Nov 3, 2025
Dr. Fanny Elahi, a physician-scientist and Associate Professor at Mount Sinai, tackles the pressing issue of Alzheimer’s disease, focusing on its higher rates among women. She explains the influence of hormonal changes during menopause and explores the promise of blood biomarkers for early detection. Delving into genetics, she discusses the APOE4 gene and its interaction with hormonal factors. Dr. Elahi also shares her optimism about upcoming breakthroughs in treatments and prevention, highlighting advances in research and FDA approvals.
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Menopause May Raise Alzheimer's Risk
- Women's midlife menopause is a major physiological transition that may raise Alzheimer's vulnerability.
- Studying why women's brains are more vulnerable could reveal key drivers of neurodegeneration.
Start Hormone Therapy Early If Appropriate
- Do consider hormone replacement perimenopause rather than waiting until later in life.
- Balance timing and duration against cancer and aging-related risks when deciding therapy.
Genetics Interact With Hormones
- APOE4 interacts with hormones and is a major genetic Alzheimer's risk factor.
- Maternal inheritance and ancestral metabolic factors may also contribute to heritability.