In this conversation, Adam Frank, a Professor of Astrophysics at the University of Rochester and author of "The Little Book of Aliens," dives into the captivating search for extraterrestrial life. He shares insights on the Drake Equation and its implications for intelligent civilizations. The discussion also covers atmospheric biosignatures and technosignatures, crucial for identifying life beyond Earth. Finally, Frank explores the philosophical challenges of communicating with potential alien beings, sparking curiosity about humanity's place in the cosmos.